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VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Vascular Endothelial Growth Factor A
Descriptor
Spanish
:
Factor A de Crecimiento Endotelial Vascular
Descriptor
Portuguese
:
Fator A de Crescimento do Endotélio Vascular
Synonyms
English
:
Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor-A
Tree Number:
D12.644.276.100.800.200
D12.776.467.100.800.200
D23.529.100.800.200
Definition
English
:
The original member of the
family
of endothelial cell
growth
factors referred to as
VASCULAR ENDOTHELIAL GROWTH FACTORS
. Vascular endothelial
growth
factor-A was originally isolated from tumor
cells
and referred to as "tumor angiogenesis factor" and "vascular
permeability
factor". Although expressed at high levels in certain tumor-derived
cells
it is produced by a wide variety of cell types. In addition to stimulating vascular
growth
and vascular
permeability
it may play a
role
in stimulating
VASODILATION
via NITRIC OXIDE-dependent pathways.
Alternative splicing
of the mRNA for
vascular endothelial growth factor A
results in several isoforms of the protein being produced.
History Note
English
:
2004; use VASCULAR ENDOTHELIAL GROWTH FACTOR A (NM) 2000-2002
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
38244
Unique Identifier:
D042461
Occurrence in VHL
:
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